Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24372821 | 0.81 | ATM (0.36) | ATMTDP1ACHE | |
| SCHEMBL29478858 | 0.81 | ATM (0.36) | ATMTDP1ACHE | |
| SCHEMBL15444691 | 0.81 | ATM (0.39) | ATMTDP1ACHE | |
| SCHEMBL21490319 | 0.78 | KDM4E (0.39) | ATMTDP1ACHE | |
| SCHEMBL12736703 | 0.75 | ATM (0.35) | ATMTDP1ACHE | |
| SCHEMBL805581 | 0.73 | ATM (0.34) | ATMTDP1 | |
| SCHEMBL18711586 | 0.68 | KDM4E (0.41) | ACHE | |
| SCHEMBL10513696 | 0.68 | KDM4E (0.44) | ACHE | |
| SCHEMBL31128625 | 0.68 | KDM4E (0.44) | ACHE | |
| SCHEMBL14051740 | 0.68 | PARP1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230225-A2 | PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032632-A2 | PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-05-10 | — | — | WO | disclosed |