Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KMO | O15229 | 2/20 | 0.51 |
| ▸ | RORB | Q92753 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | AGER | Q15109 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18580116 | 0.86 | TLR8 (0.51) | KDM4ETDP1KMORORBMAPT | |
| SCHEMBL5125812 | 0.84 | KDM4E (0.65) | KDM4ETDP1KMORORBLMNA | |
| SCHEMBL14564497 | 0.82 | KDM4E (0.67) | KDM4ETDP1LMNAGAAALDH1A1 | |
| SCHEMBL2562464 | 0.82 | KDM4E (0.57) | KDM4ETDP1KMORORBAKR1C2 | |
| SCHEMBL16276477 | 0.81 | JAK2 (0.58) | KDM4ETDP1LMNAGAAALDH1A1 | |
| SCHEMBL31586013 | 0.81 | KDM4E (0.77) | KDM4ETDP1RORBLMNAGAA | |
| SCHEMBL912675 | 0.81 | KDM4E (0.77) | KDM4ETDP1RORBLMNAGAA | |
| SCHEMBL9435093 | 0.81 | KDM4E (0.61) | KDM4ETDP1RORBLMNAALDH1A1 | |
| SCHEMBL22160863 | 0.81 | DHODH (0.59) | KDM4ETDP1LMNAALDH1A1MAPT | |
| SCHEMBL30832877 | 0.81 | DHODH (0.59) | KDM4ETDP1LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263755-A2 | CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070673-A2 | CYCLIC β-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-$g(a) | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |