Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.64 |
| ▸ | PDE4A | P27815 | 9/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | BMP1 | P13497 | 2/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419475 | 0.85 | PDE4A (0.59) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7414364 | 0.83 | PDE4A (0.70) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL7419350 | 0.83 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7417933 | 0.81 | PDE4A (0.62) | PDE4DPDE4APDE4BPDE4CMAPT | |
| SCHEMBL7429183 | 0.81 | PDE4A (0.71) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7418387 | 0.80 | PDE4A (0.66) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL7415074 | 0.79 | PDE4A (0.68) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7420585 | 0.79 | PDE4A (0.52) | PDE4DPDE4APDE4BPDE4CTP53 | |
| SCHEMBL7204752 | 0.79 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7423605 | 0.79 | PDE4A (0.67) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |