Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420778 | 0.90 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7420830 | 0.85 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7425488 | 0.81 | PDE4D (0.58) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7414327 | 0.81 | PDE4D (0.60) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7420132 | 0.78 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7420825 | 0.78 | PDE4D (0.62) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7416808 | 0.77 | PDE4D (0.73) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7417394 | 0.74 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7424242 | 0.73 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7423718 | 0.71 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |