Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.92 |
| ▸ | CRHBP | P24387 | 1/20 | 0.92 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.92 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431984 | 0.95 | MAPT (0.83) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL7640823 | 0.90 | MAPT (0.88) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL17888557 | 0.88 | MAPT (0.77) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL11016123 | 0.86 | MAPT (0.68) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL222442 | 0.83 | MEN1 (0.82) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL3008936 | 0.83 | MAPT (0.79) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL17986109 | 0.82 | MAPT (0.68) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL6335807 | 0.81 | MAPT (0.66) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL11294805 | 0.80 | MAPT (0.62) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL7426974 | 0.80 | TDP1 (1.00) | MAPTCRHBPCRHR2L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046590-B1 | PHEN(ALK)OXY-SUBSTITUTED OXIRANE-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION, THEIR USE AND DRUGS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-05-22 | — | — | EP | disclosed |
| US-4337267-A | HYPOKETONEMIC, HYPOGLYCEMIC, ANTIDIABETIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-29 | — | — | US | disclosed |
| WO-1982000643-A1 | SUBSTITUTED OXIRANECARBONIC ACIDS,PREPARATION AND PHARMACEUTICAL UTILISATION THEREOF | BYK GULDEN LOMBERG CHEM FAB (DE) | 1982-03-04 | — | — | WO | disclosed |
| EP-0046590-A2 | Phen(alk)oxy-substituted oxirane-carboxylic acids, process for their preparation, their use and drugs containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-03-03 | — | — | EP | disclosed |