Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20445551 | 1.00 | KMT2A (0.34) | KMT2ACRBNFKBP5BACE1CA1 | |
| SCHEMBL7433757 | 1.00 | KMT2A (0.34) | KMT2ACRBNFKBP5BACE1CA1 | |
| SCHEMBL20444035 | 1.00 | KMT2A (0.34) | KMT2ACRBNFKBP5BACE1CA1 | |
| SCHEMBL3071586 | 0.98 | CRBN (0.34) | KMT2ACRBNFKBP5CA1CA2 | |
| SCHEMBL13438779 | 0.91 | — | — | |
| SCHEMBL5991463 | 0.91 | — | — | |
| SCHEMBL845596 | 0.82 | — | — | |
| SCHEMBL3194607 | 0.82 | — | — | |
| SCHEMBL37625 | 0.82 | — | — | |
| SCHEMBL28426745 | 0.82 | KMT2A (0.33) | KMT2ACRBNFKBP5BACE1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462884-B1 | TRH DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-06-16 | — | — | EP | disclosed |
| EP-0462884-A1 | TRH derivatives, their preparations and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-12-27 | — | — | EP | disclosed |