Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.63 |
| ▸ | BCR | P11274 | 2/20 | 0.63 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740985 | 0.92 | AURKA (0.77) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL741251 | 0.90 | AURKA (0.64) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL743704 | 0.88 | ABL1 (0.64) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL1779351 | 0.87 | AURKA (0.69) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4632686 | 0.85 | AURKA (0.47) | AURKAKITFLT3 | |
| SCHEMBL740292 | 0.85 | AURKA (0.55) | AURKAABL1BCR | |
| SCHEMBL740888 | 0.85 | AURKA (0.66) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL740102 | 0.84 | AURKA (0.65) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL739851 | 0.83 | AURKA (0.65) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL742821 | 0.83 | AURKA (0.65) | AURKAABL1BCRKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | claimed |
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |