Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.66 |
| ▸ | F2 | P00734 | 2/20 | 0.66 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.66 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.66 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.56 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | KLK1 | P06870 | 2/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 3/20 | 0.49 |
| ▸ | RXRB | P28702 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propane SCHEMBL27557200 | 0.95 | PRSS1 (0.61) | PRSS1F2PRSS2PRSS3LOXL2 | |
| Propane SCHEMBL8503848 | 0.95 | PRSS1 (0.61) | PRSS1F2PRSS2PRSS3LOXL2 | |
| SCHEMBL27650063 | 0.88 | PRSS1 (0.63) | PRSS1F2PRSS2PRSS3LOXL2 | |
| SCHEMBL16180747 | 0.88 | PARP10 (0.64) | PRSS1F2PRSS2PRSS3LOXL2 | |
| SCHEMBL22688039 | 0.86 | PRSS1 (0.66) | PRSS1F2PRSS2PRSS3LOXL2 | |
| Hydrochloric Acid SCHEMBL7426558 | 0.86 | PRSS1 (0.61) | PRSS1F2PRSS2PRSS3LOXL2 | |
| SCHEMBL4597931 | 0.85 | PARP10 (0.62) | PRSS1F2PRSS2PRSS3PARP10 | |
| SCHEMBL7536846 | 0.85 | PARP10 (0.62) | PRSS1F2PRSS2PRSS3PARP10 | |
| SCHEMBL376498 | 0.85 | PARP10 (0.62) | PRSS1F2PRSS2PRSS3PARP10 | |
| SCHEMBL16180672 | 0.85 | PRSS1 (0.64) | PRSS1F2PRSS2PRSS3LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073624-A1 | AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS | Proteus Molecular Design Limited (GB) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055661-A1 | AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS | PROTEUS MOLECULAR DESIGN LIMITED (GB) | 1999-11-04 | — | — | WO | disclosed |