Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439029 | 1.00 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL7430471 | 1.00 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL7423498 | 0.89 | ACE (0.62) | ACE | |
| SCHEMBL7424221 | 0.89 | ACE (0.62) | ACE | |
| SCHEMBL7423494 | 0.89 | ACE (0.62) | ACE | |
| SCHEMBL9525613 | 0.87 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9525588 | 0.87 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9526226 | 0.87 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9525593 | 0.87 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 | |
| SCHEMBL9530113 | 0.87 | ACE (0.56) | ACEABCB11AGTR2PDE3ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120728-A1 | Thiazine and thiazepine containing compounds | E.R. Squibb & Sons, Inc. (US) | 1984-10-03 | — | — | EP | disclosed |
| US-4460579-A | HYPOTENSIVE AGENTS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-17 | — | — | US | disclosed |