Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.70 |
| ▸ | EDNRB | P24530 | 12/20 | 0.70 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | DHPS | P49366 | 1/20 | 0.65 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.65 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819733 | 0.90 | EDNRA (0.64) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL5682394 | 0.87 | EDNRA (0.87) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL2438810 | 0.85 | EDNRA (0.72) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL3667814 | 0.84 | EDNRA (0.56) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7795452 | 0.83 | EDNRA (0.93) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL13430590 | 0.80 | EDNRA (0.81) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL15257223 | 0.80 | EDNRA (0.86) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7787008 | 0.79 | EDNRA (0.86) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7795460 | 0.79 | EDNRA (0.97) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| Bosentan SCHEMBL902870 | 0.79 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254121-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055120-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-02 | — | — | WO | disclosed |