Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S | Q13698 | 12/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | HRH2 | P25021 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | SCN1A | P35498 | 1/20 | 0.57 |
| ▸ | SCN4A | P35499 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.57 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.57 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.57 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429621 | 1.00 | CACNA1S (0.68) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL7429614 | 1.00 | CACNA1S (0.68) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Hydrochloric Acid SCHEMBL11091156 | 0.99 | CACNA1S (0.67) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Hydrochloric Acid SCHEMBL10914928 | 0.99 | CACNA1S (0.67) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Hydrochloric Acid SCHEMBL10831016 | 0.99 | CACNA1S (0.67) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Acetic Acid SCHEMBL9853367 | 0.96 | CACNA1S (0.65) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL7295775 | 0.93 | CACNA1S (0.66) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL7293674 | 0.93 | CACNA1S (0.66) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL9503765 | 0.92 | CACNA1S (0.60) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL10831035 | 0.92 | CACNA1S (0.57) | CACNA1SCYP3A4TSHRABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61103877-A | — | — | None | — | — | JP | disclosed |
| US-5387581-A | Pharmaceutical composition of aspirin and a benzothiazepine for inhibiting platelet aggregation | TANABE SEIYAKU CO. LTD. (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0476854-B1 | Pharmaceutical composition for inhibiting platelet aggregation | TANABE SEIYAKU CO (JP) | 1994-06-08 | — | — | EP | disclosed |
| US-5134139-A | Antiarrhythmia agents, blood metal antagonist, hypotensive agents or vasodilator agents | TANABE SEIYAKU CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0476854-A1 | Pharmaceutical composition for inhibiting platelet aggregation | TANABE SEIYAKU CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |
| EP-0416479-A1 | 1,5-Benzothiazepine derivatives and preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1991-03-13 | — | — | EP | disclosed |
| EP-0127882-B1 | NOVEL 8-CHLORO-1,5-BENZOTHIAZEPINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS | Tanabe Seiyaku Co., Ltd. (JP) | 1986-10-15 | — | — | EP | disclosed |
| JP-S61103877-A | BENZOTHIAZEPINE DERIVATIVE AND ITS PREPARATION | TANABE SEIYAKU CO LTD | 1986-05-22 | — | — | JP | disclosed |
| US-4567175-A | HYPOTENSIVE AGENTS, CORONARY OR CEREBRAL VASODILATORS | TANABE SEIYAKU CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| EP-0127882-A1 | Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1984-12-12 | — | — | EP | disclosed |