Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423509 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| Hydrochloric Acid SCHEMBL10739661 | 0.89 | SMN1; SMN2 (0.54) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| SCHEMBL7427653 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| SCHEMBL10509690 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| Hydrochloric Acid SCHEMBL7432871 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| Hydrochloric Acid SCHEMBL7434273 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| SCHEMBL18723410 | 0.85 | SLC6A2 (0.50) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| SCHEMBL1856103 | 0.84 | CA1 (0.51) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| SCHEMBL1859677 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2AMEN1HTTHPGD | |
| SCHEMBL7427195 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2AMEN1NPC1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061745-A1 | Tetrahydroisoquinoline compounds, processes for preparation thereof and pharmaceutical composition containing them | Tanabe Seiyaku Co., Ltd. (JP) | 1982-10-06 | — | — | EP | disclosed |