Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KLK7 | P49862 | 1/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 4/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.53 |
| ▸ | CTSB | P07858 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16274170 | 1.00 | SYK (0.63) | SYKMAPTKLK7KLK5CTSS | |
| SCHEMBL14561127 | 0.94 | SYK (0.61) | SYKMAPTKLK7KLK5CTSS | |
| SCHEMBL1021719 | 0.93 | SYK (0.63) | SYKMAPTKLK7KLK5CTSS | |
| SCHEMBL5441822 | 0.93 | SYK (0.63) | SYKMAPTKLK7KLK5CTSS | |
| SCHEMBL1197897 | 0.93 | SYK (0.63) | SYKMAPTKLK7KLK5CTSS | |
| SCHEMBL17882090 | 0.92 | SYK (0.57) | SYKMAPTKLK7KLK5CTSS | |
| SCHEMBL27497192 | 0.92 | KLK7 (0.63) | SYKMAPTKLK7KLK5POLB | |
| SCHEMBL30544856 | 0.92 | KLK7 (0.63) | SYKMAPTKLK7KLK5POLB | |
| SCHEMBL16269962 | 0.92 | SYK (0.58) | SYKMAPTKLK7KLK5CTSS | |
| SCHEMBL23574171 | 0.91 | SYK (0.60) | SYKMAPTKLK7KLK5CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |