Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29619671 | 1.00 | DPP4 (0.53) | DPP4DPP7CYP3A4DPP8 | |
| SCHEMBL743991 | 1.00 | DPP4 (0.53) | DPP4DPP7CYP3A4DPP8 | |
| SCHEMBL25663563 | 1.00 | DPP4 (0.53) | DPP4DPP7CYP3A4DPP8 | |
| SCHEMBL571909 | 1.00 | DPP4 (0.53) | DPP4DPP7CYP3A4DPP8 | |
| Hydrochloric Acid SCHEMBL3702345 | 0.98 | DPP4 (0.53) | DPP4DPP7DPP8 | |
| SCHEMBL28687928 | 0.86 | DPP4 (0.51) | DPP4DPP7CYP3A4DPP8 | |
| Mandelic Acid SCHEMBL30307007 | 0.85 | DPP4 (0.48) | DPP4DPP7CYP3A4DPP8 | |
| SCHEMBL1644943 | 0.85 | DPP4 (0.51) | DPP4DPP7CYP3A4DPP8 | |
| SCHEMBL22950634 | 0.85 | DPP4 (0.49) | DPP4DPP7CYP3A4DPP8 | |
| SCHEMBL22950624 | 0.85 | DPP4 (0.49) | DPP4DPP7CYP3A4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023012819-A1 | RECOMBINANT TRANSAMINASE POLYPEPTIDES | QUANTUMZYME LLP (IN) | 2023-02-09 | — | — | WO | claimed |
| US-20120108598-A1 | SITAGLIPTIN SYNTHESIS | MYLAN INDIA PRIVATE LIMITED (IN) | 2012-05-03 | — | — | US | claimed |
| EP-2430025-A1 | SITAGLIPTIN SYNTHESIS | Generics [UK] Limited (GB) | 2012-03-21 | — | — | EP | claimed |
| WO-2010122578-A2 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES | MSN LABORATORIES LIMITED (IN) | 2010-10-28 | — | — | WO | claimed |
| US-11932886-B2 | Engineered transaminase polypeptides and uses thereof | ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD. (CN) | 2024-03-19 | — | — | US | disclosed |
| CN-115819260-B | Synthesis process of sitagliptin intermediate | 江苏阿尔法药业股份有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-116514656-A | Synthesis process of sitagliptin intermediate | 江苏阿尔法药业股份有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-116064457-A | Omega-aminotransferase mutant and application thereof | 浙江工业大学 | 2023-05-05 | — | — | CN | disclosed |
| CN-115819260-A | Synthesis process of sitagliptin intermediate | 江苏阿尔法药业股份有限公司 | 2023-03-21 | — | — | CN | disclosed |
| WO-2023021529-A1 | IMPROVED ENZYMATIC SYNTHESIS OF SITAGLIPTIN OR ITS SALTS THEREOF | FERMENTA BIOTECH LIMITED (IN) | 2023-02-23 | — | — | WO | disclosed |
| CN-112048485-B | Engineered transaminase polypeptide for preparing sitagliptin | 宁波酶赛生物工程有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-112048485-A | Engineered transaminase polypeptide for preparing sitagliptin | 宁波酶赛生物工程有限公司 | 2020-12-08 | — | — | CN | disclosed |
| WO-2012017391-A2 | NOVEL COMPOUNDS AS DPP-IV INHIBITORS AND PROCESS FOR PREPARATION THEREOF | CADILA PHARMACEUTICALS LIMITED (IN) | 2012-02-09 | — | — | WO | disclosed |
| EP-2415754-A2 | IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | Dong-A Pharmaceutical Co., Ltd. (KR) | 2012-02-08 | — | — | EP | disclosed |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DONG-A PHARMACEUTICAL. CO., LTD (KR) | 2012-01-19 | — | — | US | disclosed |
| WO-2010122578-A2 | PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES | MSN LABORATORIES LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010114291-A2 | IMPROVED METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | 동아제약 주식회사 (KR) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114292-A2 | IMPROVED METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | 동아제약 주식회사 (KR) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016126-A1 | METHOD FOR MANUFACTURING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DPP4, DPP3, DPP7 | DPP4 1/4885DPP7 3/4885CYP3A4 234/4885 |
| US-20120016125-A1 | METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE | DPP4, DPP3, DPP7 | DPP4 1/4885DPP7 3/4885CYP3A4 205/4885 |
| US-20120108598-A1 | SITAGLIPTIN SYNTHESIS | DPP4, DPP7, DPP3 | DPP4 1/4885DPP7 2/4885CYP3A4 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.