Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95059 | 0.75 | PRCP (0.53) | HTR2ASMN1; SMN2PRCPTSHRNPSR1 | |
| SCHEMBL1799182 | 0.75 | PRCP (0.53) | HTR2ASMN1; SMN2PRCPTSHRNPSR1 | |
| SCHEMBL9627333 | 0.74 | PRCP (0.56) | HTR2ARETNPC1MAPK13MAPK12 | |
| SCHEMBL28967711 | 0.72 | PRCP (0.42) | CYP1A2CYP2D6CYP2C9CYP2C19CAMK2A | |
| SCHEMBL7433419 | 0.72 | HTR2A (0.42) | HTR2ARETNPC1MAPK13MAPK12 | |
| SCHEMBL2601579 | 0.71 | ACP3 (0.48) | HTR2ARETACP3CYP1A2CYP2D6 | |
| SCHEMBL3087062 | 0.71 | CYP2D6 (0.38) | CYP1A2CYP2D6CYP2C9CYP2C19PRCP | |
| SCHEMBL30435099 | 0.71 | CYP2D6 (0.38) | CYP1A2CYP2D6CYP2C9CYP2C19PRCP | |
| SCHEMBL22799647 | 0.70 | TSHR (0.37) | HTR2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5191604 | 0.66 | HTR2C (0.46) | HTR2ARETACP3SMN1; SMN2PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462884-B1 | TRH DERIVATIVES, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1993-06-16 | — | — | EP | disclosed |
| US-5190923-A | For treatment of neurological disorders such as cognitive disorders | ADIR ET COMPAGNIE (FR) | 1993-03-02 | — | — | US | disclosed |
| EP-0462884-A1 | TRH derivatives, their preparations and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-12-27 | — | — | EP | disclosed |