Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.48 |
| ▸ | PRKCG | P05129 | 3/20 | 0.48 |
| ▸ | PRKCB | P05771 | 3/20 | 0.48 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | PRKCH | P24723 | 3/20 | 0.48 |
| ▸ | PRKCI | P41743 | 3/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427506 | 0.97 | MELK (0.54) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| SCHEMBL7426350 | 0.93 | MELK (0.56) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| SCHEMBL7425086 | 0.89 | MELK (0.58) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| SCHEMBL7430002 | 0.83 | MELK (0.50) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| SCHEMBL1272416 | 0.81 | MELK (0.58) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| Hydrochloric Acid SCHEMBL1165285 | 0.80 | MELK (0.59) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| Hydrochloric Acid SCHEMBL7432249 | 0.80 | MELK (0.59) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| SCHEMBL10983757 | 0.78 | PRKD3 (0.56) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| SCHEMBL7426552 | 0.77 | PRKD3 (0.48) | MELKMAPK1CAMKK2PRKD3PRKCG | |
| SCHEMBL7429288 | 0.76 | PRKD3 (0.51) | MELKMAPK1CAMKK2PRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4709032-A | VASODILATION AND HYPOTENSIVE AGENT | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1987-11-24 | — | — | US | disclosed |
| US-4634770-A | VASODILATORS, HYPOTENSIVES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1987-01-06 | — | — | US | disclosed |
| EP-0109023-A1 | Isoquinolinesulfonamide derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-05-23 | — | — | EP | disclosed |