Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | TNF | P01375 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285246 | 0.91 | TP53 (0.57) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL6288909 | 0.91 | TP53 (0.57) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL4857900 | 0.91 | TP53 (0.57) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL4856275 | 0.90 | TP53 (0.60) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL6287582 | 0.90 | TP53 (0.60) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL6289218 | 0.90 | TP53 (0.60) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL7436599 | 0.88 | TP53 (0.57) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL7441919 | 0.88 | TP53 (0.55) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL6286599 | 0.88 | TP53 (0.54) | MEN1KMT2ATP53TNFPDE4A | |
| SCHEMBL6289221 | 0.88 | TP53 (0.54) | MEN1KMT2ATP53TNFPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703098-A | INHIBITORS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-30 | — | — | US | claimed |
| EP-0797437-B1 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNFalpha | CELGENE CORP (US) | 2001-04-18 | — | — | EP | disclosed |
| EP-0942902-A2 | NOVEL IMMUNOTHERAPEUTIC IMIDES/AMIDES | CELGENE CORPORATION (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998024763-A2 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AS PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-06-11 | — | — | WO | disclosed |
| US-5703098-A | INHIBITORS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |