Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 19/20 | 0.39 |
| ▸ | CDK9 | P50750 | 19/20 | 0.39 |
| ▸ | CDK4 | P11802 | 5/20 | 0.39 |
| ▸ | CCND1 | P24385 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK3 | Q00526 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 3/20 | 0.34 |
| ▸ | CCNH | P51946 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441316 | 0.88 | DPP4 (0.42) | DPP4 | |
| SCHEMBL7438702 | 0.88 | DPP4 (0.42) | DPP4 | |
| SCHEMBL7433754 | 0.85 | DPP4 (0.41) | DPP4 | |
| SCHEMBL7438343 | 0.85 | DPP4 (0.41) | DPP4 | |
| SCHEMBL7438026 | 0.84 | DPP4 (0.42) | DPP4CCNT1CDK9CDK4CCND1 | |
| SCHEMBL7442347 | 0.84 | DPP4 (0.40) | DPP4 | |
| SCHEMBL7437185 | 0.84 | DPP4 (0.39) | DPP4CCNT1CDK9CDK2CDK7 | |
| SCHEMBL7441612 | 0.83 | DPP4 (0.39) | DPP4 | |
| SCHEMBL7433851 | 0.82 | DPP4 (0.36) | DPP4 | |
| SCHEMBL7442649 | 0.82 | DPP4 (0.38) | DPP4CCNT1CDK9CDK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |