Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.42 |
| ▸ | TGM2 | P21980 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433569 | 0.91 | CYP1A2 (0.49) | CYP1A2CYP2C9CYP2C19AVPR2AVPR1A | |
| Hydrochloric Acid SCHEMBL7429640 | 0.90 | CYP1A2 (0.48) | CYP1A2CYP2C9CYP2C19AVPR2AVPR1A | |
| SCHEMBL7437630 | 0.90 | CYP1A2 (0.56) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL7438698 | 0.90 | CYP1A2 (0.58) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL7437704 | 0.89 | CYP1A2 (0.53) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL7440422 | 0.88 | CYP1A2 (0.52) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL7439105 | 0.87 | CYP1A2 (0.51) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL7431018 | 0.84 | CYP1A2 (0.51) | CYP1A2CYP2C9CYP2C19ALDH1A1TP53 | |
| SCHEMBL7483493 | 0.84 | CYP1A2 (0.52) | CYP1A2CYP2C9CYP2C19TP53MEN1 | |
| SCHEMBL7431049 | 0.83 | CYP1A2 (0.49) | CYP1A2CYP2C9CYP2C19ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |