Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.76 |
| ▸ | PDE4A | P27815 | 15/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.76 |
| ▸ | TNF | P01375 | 3/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288775 | 0.89 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL7445922 | 0.89 | TNF (0.84) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL20474741 | 0.89 | PDE4B (0.73) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL537289 | 0.88 | PDE4A (0.76) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL537150 | 0.88 | PDE4A (0.76) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL23000612 | 0.87 | PDE4A (0.80) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL21494489 | 0.87 | PDE4A (0.80) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL537194 | 0.87 | PDE4B (0.75) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL21494487 | 0.87 | PDE4A (0.80) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL537164 | 0.87 | PDE4B (0.75) | PDE4BPDE4CPDE4APDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942902-A2 | NOVEL IMMUNOTHERAPEUTIC IMIDES/AMIDES | CELGENE CORPORATION (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998024763-A2 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AS PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-06-11 | — | — | WO | disclosed |
| US-5703098-A | INHIBITORS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |