Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TOP1 | P11387 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435677 | 0.87 | PDE4A (0.85) | PDE4APDE4BPDE4DPDE4CTDP1 | |
| SCHEMBL7432993 | 0.87 | PDE4A (0.80) | PDE4APDE4BPDE4DPDE4CMEN1 | |
| SCHEMBL29367114 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CKMT2A | |
| SCHEMBL3698956 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CKMT2A | |
| SCHEMBL7434132 | 0.84 | PDE4A (0.79) | PDE4APDE4BPDE4DPDE4CTDP1 | |
| SCHEMBL7450694 | 0.83 | PDE4A (0.74) | PDE4APDE4BPDE4DPDE4CMEN1 | |
| SCHEMBL7442528 | 0.82 | PDE4A (0.80) | PDE4APDE4BPDE4DPDE4CTOP1 | |
| SCHEMBL7439484 | 0.81 | PDE4A (0.71) | PDE4APDE4BPDE4DPDE4CMEN1 | |
| SCHEMBL7444919 | 0.81 | PDE4A (0.71) | PDE4APDE4BPDE4DPDE4CMEN1 | |
| SCHEMBL7441893 | 0.81 | PDE4A (0.74) | PDE4APDE4BPDE4DPDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |