Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 4/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14480077 | 0.84 | CREBBP (0.50) | PROKR1MAPTKMT2ANPSR1ACACB | |
| SCHEMBL1992514 | 0.84 | MAPT (0.57) | PROKR1MAPTKMT2ANPSR1JMJD6 | |
| SCHEMBL30723841 | 0.84 | MAPT (0.57) | PROKR1MAPTKMT2ANPSR1JMJD6 | |
| SCHEMBL6241029 | 0.83 | PARP10 (0.51) | PROKR1MAPTKMT2ANPSR1ACACB | |
| SCHEMBL17478456 | 0.83 | MAPT (0.56) | PROKR1MAPTKMT2ANPSR1JMJD6 | |
| SCHEMBL30281260 | 0.83 | PARP10 (0.51) | PROKR1MAPTKMT2ANPSR1ACACB | |
| SCHEMBL31637653 | 0.82 | KCNK3 (0.50) | PROKR1CTSA | |
| SCHEMBL2431121 | 0.82 | KCNK3 (0.50) | PROKR1CTSA | |
| SCHEMBL29173821 | 0.81 | KDM4E (0.55) | PROKR1MAPTACACBJMJD6NPC1 | |
| SCHEMBL3723629 | 0.81 | JMJD6 (0.56) | JMJD6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059948-B1 | NOVEL AROYLIMIDAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-11-13 | — | — | EP | disclosed |
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |
| EP-0059948-A1 | Novel aroylimidazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-09-15 | — | — | EP | disclosed |