Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.70 |
| ▸ | TNF | P01375 | 8/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434917 | 0.94 | TNF (0.72) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7432935 | 0.94 | TNF (0.67) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7432712 | 0.92 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7433895 | 0.91 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7445922 | 0.88 | TNF (0.84) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7436772 | 0.87 | TNF (0.67) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL9977580 | 0.85 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL9977550 | 0.85 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL7432606 | 0.83 | TNF (0.77) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL6287556 | 0.83 | TNF (0.71) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942902-A2 | NOVEL IMMUNOTHERAPEUTIC IMIDES/AMIDES | CELGENE CORPORATION (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998024763-A2 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AS PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-06-11 | — | — | WO | disclosed |
| US-5703098-A | INHIBITORS OF CYTOKINES INCLUDING TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-30 | — | — | US | disclosed |