Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.66 |
| ▸ | ITGB3 | P05106 | 15/20 | 0.66 |
| ▸ | ITGB6 | P18564 | 8/20 | 0.61 |
| ▸ | ITGB8 | P26012 | 8/20 | 0.61 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438006 | 1.00 | ITGAV (0.66) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7441211 | 1.00 | ITGAV (0.66) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7544845 | 0.91 | ITGAV (0.62) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7442229 | 0.91 | ITGAV (0.80) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7439008 | 0.91 | ITGAV (0.80) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL5824333 | 0.91 | ITGAV (0.80) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7443940 | 0.89 | ITGAV (0.81) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7441291 | 0.89 | ITGAV (0.81) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7439662 | 0.89 | ITGAV (0.81) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7439482 | 0.88 | ITGAV (0.66) | ITGAVITGB3ITGB6ITGB8ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187592-A4 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | claimed |
| EP-1187592-A2 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2002-03-20 | — | — | EP | claimed |
| WO-2000072801-A2 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-12-07 | — | — | WO | claimed |
| US-6410526-B1 | BONE DISORDERS; RESTENOSIS; VISION DISORDERS; ANTICHOLESTEROL AGENTS; ANTICANCER, ANTITUMOR AGENTS | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |