Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.69 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038802 | 0.85 | PDE4A (0.69) | PDE4APDE4BPDE4DPDE4CCYP2C9 | |
| SCHEMBL7436085 | 0.84 | PDE4A (0.59) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL7441348 | 0.84 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE4CDHFR | |
| SCHEMBL13849048 | 0.84 | PDE4A (0.68) | PDE4APDE4BPDE4DPDE4CCYP2C9 | |
| SCHEMBL4038041 | 0.84 | PDE4A (0.68) | PDE4APDE4BPDE4DPDE4CCYP2C9 | |
| SCHEMBL4038039 | 0.84 | PDE4A (0.68) | PDE4APDE4BPDE4DPDE4CCYP2C9 | |
| SCHEMBL7450702 | 0.83 | PDE4A (0.60) | PDE4APDE4BPDE4DPDE4CMAPT | |
| SCHEMBL7436994 | 0.83 | PDE4A (0.63) | PDE4APDE4BPDE4DPDE4CDHFR | |
| SCHEMBL14402844 | 0.83 | PDE4A (0.76) | PDE4APDE4BPDE4DPDE4CCYP2C9 | |
| SCHEMBL6180387 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |