Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PDE1A | P54750 | 2/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PARN | O95453 | 1/20 | 0.39 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438608 | 1.00 | GAA (0.47) | GAASMN1; SMN2ADORA2BRXFP1HPGD | |
| SCHEMBL7441118 | 0.98 | GAA (0.47) | GAASMN1; SMN2ADORA2BRXFP1HPGD | |
| SCHEMBL7441123 | 0.98 | GAA (0.47) | GAASMN1; SMN2ADORA2BRXFP1HPGD | |
| SCHEMBL7442334 | 0.89 | SMN1; SMN2 (0.44) | GAASMN1; SMN2ADORA2BRXFP1HPGD | |
| SCHEMBL7442326 | 0.89 | SMN1; SMN2 (0.44) | GAASMN1; SMN2ADORA2BRXFP1HPGD | |
| SCHEMBL7438356 | 0.87 | PDE5A (0.44) | GAASMN1; SMN2HPGDTSHRMAPK1 | |
| SCHEMBL7438364 | 0.87 | PDE5A (0.44) | GAASMN1; SMN2HPGDTSHRMAPK1 | |
| SCHEMBL7446214 | 0.83 | MAPK1 (0.46) | SMN1; SMN2HPGDTSHRMAPK1TP53 | |
| SCHEMBL7440766 | 0.83 | MAPK1 (0.46) | SMN1; SMN2HPGDTSHRMAPK1TP53 | |
| SCHEMBL7431286 | 0.83 | MAPK1 (0.46) | SMN1; SMN2HPGDTSHRMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |