Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ACE | P12821 | 3/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445733 | 0.97 | GAA (0.52) | GAACYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL29833544 | 0.92 | GAA (0.56) | GAACYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL4799545 | 0.92 | GAA (0.56) | GAACYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL7543359 | 0.92 | GAA (0.56) | GAACYP1A2CYP2C9CYP2C19MAPT | |
| Cadaverine Tartrate SCHEMBL4805491 | 0.85 | GAA (0.53) | GAACYP1A2CYP2C9CYP2C19MAPT | |
| Cadaverine Tartrate SCHEMBL10907408 | 0.85 | GAA (0.53) | GAACYP1A2CYP2C9CYP2C19MAPT | |
| Cadaverine Tartrate SCHEMBL4805487 | 0.85 | GAA (0.53) | GAACYP1A2CYP2C9CYP2C19MAPT | |
| Cadaverine Tartrate SCHEMBL10907406 | 0.85 | GAA (0.53) | GAACYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL10596467 | 0.83 | PDPK1 (0.53) | ACE | |
| SCHEMBL7442616 | 0.82 | PDPK1 (0.44) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0119161-B1 | BENZAZOCINONE AND BENZAZONINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS, AND THEIR THERAPEUTICAL USE | CIBA-GEIGY AG (CH) | 1989-06-28 | — | — | EP | disclosed |
| US-4537885-A | SUBSTITUTED 1-CARBOXY-3-(CARBOXYMETHYLAMINO)-2-ONE DERIVATIVES, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | CIBA GEIGY CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0119161-A2 | Benzazocinone and benzazoninone derivatives, process for their preparation, pharmaceutical preparations containing these compounds, and their therapeutical use | CIBA-GEIGY AG (CH) | 1984-09-19 | — | — | EP | disclosed |
| US-4470988-A | HYPOTENSIVE AGENTS, ENZYME INHIBITOR, CARDIAC DISORDERS | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |