Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437536 | 0.89 | TP53 (0.53) | MEN1KMT2ATP53ALDH1A1MAPT | |
| SCHEMBL4864524 | 0.88 | MEN1 (0.56) | MEN1KMT2AHPGDTP53ALDH1A1 | |
| SCHEMBL7438698 | 0.83 | CYP1A2 (0.58) | MEN1KMT2AHPGDTP53ALDH1A1 | |
| SCHEMBL7435530 | 0.83 | CYP1A2 (0.63) | TP53CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7437630 | 0.82 | CYP1A2 (0.56) | MEN1KMT2ATP53ALDH1A1MAPT | |
| SCHEMBL7429152 | 0.81 | CYP1A2 (0.60) | TP53CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7679388 | 0.81 | CNR2 (0.40) | MEN1KMT2AHPGDMAPTHTT | |
| SCHEMBL7437704 | 0.80 | CYP1A2 (0.53) | MEN1KMT2ATP53ALDH1A1MAPT | |
| SCHEMBL7685015 | 0.79 | CYP1A2 (0.57) | TP53PKMHTTCYP1A2CYP2C9 | |
| SCHEMBL7432412 | 0.79 | CYP1A2 (0.57) | TP53CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | claimed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | claimed |
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |