Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15178373 | 0.89 | IDO1 (0.43) | IDO1GPR119HRH3PKMNAMPT | |
| SCHEMBL15178335 | 0.88 | IDO1 (0.41) | IDO1GPR119HRH3PKMNAMPT | |
| SCHEMBL309455 | 0.85 | IDO1 (0.41) | IDO1GPR119HRH3PKMNAMPT | |
| SCHEMBL309454 | 0.85 | IDO1 (0.41) | IDO1GPR119HRH3PKMNAMPT | |
| SCHEMBL309181 | 0.82 | IDO1 (0.45) | IDO1GPR119 | |
| SCHEMBL743373 | 0.82 | IDO1 (0.43) | IDO1GPR119HRH3NAMPT | |
| SCHEMBL309180 | 0.82 | IDO1 (0.45) | IDO1GPR119 | |
| SCHEMBL741130 | 0.81 | IDO1 (0.35) | IDO1GPR119NAMPT | |
| SCHEMBL1815579 | 0.78 | IDO1 (0.41) | IDO1GPR119HRH3PKMNAMPT | |
| SCHEMBL309170 | 0.78 | IDO1 (0.41) | IDO1GPR119HRH3PKMNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | IDO1 280/4885GPR119 1243/4885HRH3 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.