Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28844529 | 0.79 | SMN1; SMN2 (0.37) | SMN1; SMN2L3MBTL1POLBATMALDH1A1 | |
| SCHEMBL10635951 | 0.75 | AOC3 (0.48) | L3MBTL1POLBATMHTTLMNA | |
| Hydrochloric Acid SCHEMBL18553839 | 0.74 | MEN1 (0.40) | SMN1; SMN2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL10838992 | 0.73 | CYP2C19 (0.43) | SMN1; SMN2L3MBTL1POLBATMALDH1A1 | |
| SCHEMBL3234142 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1ATMALDH1A1MEN1 | |
| SCHEMBL479277 | 0.71 | CYP3A4 (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL1387573 | 0.71 | CYP3A4 (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8119644 | 0.71 | CYP3A4 (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2AHTT | |
| Hydrochloric Acid SCHEMBL2322263 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1ATMALDH1A1MEN1 | |
| SCHEMBL10582023 | 0.70 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1POLBATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652892-B1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1997-08-20 | — | — | EP | disclosed |
| EP-0652892-A1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY. | ZENECA LTD (GB) | 1995-05-17 | — | — | EP | disclosed |
| US-5405852-A | Amide derivatives | ZENECA LIMITED (GB) | 1995-04-11 | — | — | US | disclosed |
| WO-1993024519-A1 | LACTAM DIPEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-12-09 | — | — | WO | disclosed |