Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.82 |
| ▸ | ITGB3 | P05106 | 16/20 | 0.82 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.70 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.67 |
| ▸ | ITGB6 | P18564 | 5/20 | 0.66 |
| ▸ | ITGB8 | P26012 | 5/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448931 | 1.00 | ITGAV (0.82) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7444473 | 1.00 | ITGAV (0.82) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6421874 | 0.92 | ITGAV (0.85) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6421564 | 0.90 | ITGAV (1.00) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6359531 | 0.90 | ITGAV (1.00) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6421303 | 0.90 | ITGAV (1.00) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7434911 | 0.87 | ITGAV (0.85) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7447983 | 0.87 | ITGAV (0.85) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7439077 | 0.87 | ITGAV (0.85) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL7433674 | 0.87 | ITGAV (0.64) | ITGAVITGB3ITGA2BITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1589145-A | Alpha v integrin receptor antagonists | MERCK & CO INC (US) | 2005-03-02 | — | — | CN | disclosed |
| US-6410526-B1 | BONE DISORDERS; RESTENOSIS; VISION DISORDERS; ANTICHOLESTEROL AGENTS; ANTICANCER, ANTITUMOR AGENTS | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |