Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | TYR | P14679 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11714770 | 0.89 | HTT (0.90) | HTTTSHRTYRALDH1A1KDM4E | |
| SCHEMBL19766699 | 0.89 | HTT (0.90) | HTTTSHRTYRALDH1A1KDM4E | |
| SCHEMBL2540114 | 0.85 | HTT (0.90) | HTTTSHRTYRALDH1A1KDM4E | |
| SCHEMBL2535573 | 0.84 | HTT (0.88) | HTTTSHRTYRALDH1A1KDM4E | |
| SCHEMBL597286 | 0.83 | GAA (0.57) | HTTTSHRALDH1A1KDM4EPOLB | |
| SCHEMBL10293624 | 0.83 | HTT (0.79) | HTTTSHRTYRALDH1A1KDM4E | |
| SCHEMBL595000 | 0.81 | HTT (0.72) | HTTTSHRTYRALDH1A1KDM4E | |
| SCHEMBL12766946 | 0.81 | HTT (0.72) | HTTTSHRTYRALDH1A1KDM4E | |
| SCHEMBL9579269 | 0.81 | HTT (0.72) | HTTTSHRTYRALDH1A1KDM4E | |
| SCHEMBL1797086 | 0.81 | TSHR (0.59) | HTTTSHRALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |