SCHEMBL7440132

SCHEMBL7440132

O=C1NS(=O)(=O)N[C@H]1Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 2/20 0.46
GAA P10253 2/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP1A2 P05177 1/20 0.43
POLB P06746 1/20 0.40
DDB1 Q16531 1/20 0.39
CRBN Q96SW2 1/20 0.39
CA2 P00918 1/20 0.39
MAOB P27338 1/20 0.39
PLA2G10 O15496 1/20 0.39
PLA2G5 P39877 1/20 0.39
ALDH1A1 P00352 1/20 0.38
CYP2C9 P11712 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7333420 1.00 HDAC8 (0.46) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL9085097 0.98 HDAC8 (0.45) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL13399577 0.74 HDAC8 (0.56) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL18751777 0.74 HDAC8 (0.56) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL10283637 0.74 HDAC8 (0.56) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL1226583 0.74 HDAC8 (0.56) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL1405670 0.74 HDAC8 (0.56) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL15762027 0.70 HDAC8 (0.49) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL15762024 0.70 HDAC8 (0.49) HDAC8GAACYP3A4CYP2C19CYP1A2
SCHEMBL15427228 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6420401-B1 SERINE PROTEASE INHIBITOR WICHITA STATE UNIVERSITY 2002-07-16 US disclosed
EP-0739338-B1 SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE UNIV WICHITA STATE (US) 2002-04-10 EP disclosed
EP-1011668-A4 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES UNIV WICHITA STATE (US) 2001-08-16 EP disclosed
EP-1011668-A1 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES THE WICHITA STATE UNIVERSITY (US) 2000-06-28 EP disclosed
WO-1999009977-A9 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES UNIV WICHITA STATE (US) 1999-06-24 WO disclosed
WO-1999009977-A1 1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES WICHITA STATE UNIVERSITY (US) 1999-03-04 WO disclosed
EP-0739338-A4 NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE UNIV WICHITA STATE (US) 1997-03-26 EP disclosed
EP-0739338-A1 NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE THE WICHITA STATE UNIVERSITY (US) 1996-10-30 EP disclosed
US-5550139-A ANTIINFLAMMATORY AGENT, ANTITUMOR AGENT, ANTICARCINOGENIC AGENT THE WICHITA STATE UNIVERSITY (US) 1996-08-27 US disclosed
WO-1995018797-A1 NOVEL SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE THE WICHITA STATE UNIVERSITY (US) 1995-07-13 WO disclosed