Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.75 |
| ▸ | PDE1A | P54750 | 3/20 | 0.69 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.69 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9021978 | 0.86 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL9021637 | 0.85 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3012296 | 0.83 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL3023422 | 0.83 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL7446406 | 0.82 | PDE1A (1.00) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL7355633 | 0.80 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL7025694 | 0.79 | PDE5A (0.50) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL3030666 | 0.77 | PDE5A (0.55) | PDE5A | |
| SCHEMBL3023652 | 0.77 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3023136 | 0.77 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5734053-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | PFIZER INC (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0647227-B1 | PURINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0647227-A1 | PURINONE ANTIANGINAL AGENTS. | PFIZER LTD (GB) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000453-A1 | PURINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1994-01-06 | — | — | WO | disclosed |