Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429825 | 0.92 | KDM4E (0.50) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL65812 | 0.85 | KDM4E (0.60) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL3028553 | 0.81 | KDM4E (0.59) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL65929 | 0.80 | KDM4E (0.55) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL1186099 | 0.75 | KDM4E (0.68) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL1417913 | 0.73 | KDM4E (0.81) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL31590423 | 0.73 | KDM4E (0.66) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL950248 | 0.72 | KDM4E (0.64) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL3023145 | 0.72 | KDM4E (0.64) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL21227043 | 0.72 | KDM4E (0.64) | KDM4ESMN1; SMN2LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0503785-B1 | 1-Biphenylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |