Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11296145 | 0.77 | PDE3B (0.45) | NAMPTPDE3BPDE3A | |
| SCHEMBL123203 | 0.69 | KDM4C (0.51) | SIRT3TDP1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL3818724 | 0.69 | TDP1 (0.44) | SIRT3TDP1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL30465694 | 0.69 | KDM4C (0.51) | SIRT3TDP1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL9002466 | 0.68 | SIRT3 (0.61) | SIRT3TDP1CYP2E1CYP2C8CYP2D6 | |
| Acetic Acid SCHEMBL16666943 | 0.66 | KDM4C (0.49) | SIRT3TDP1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL3821293 | 0.65 | TDP1 (0.41) | SIRT3TDP1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL28859980 | 0.65 | KDM4E (0.48) | SIRT3TDP1CYP2E1CYP2C8CYP2D6 | |
| SCHEMBL4074620 | 0.65 | KDM4E (0.57) | SIRT3TDP1KDM6BKDM4C | |
| SCHEMBL12344200 | 0.65 | SIRT3 (0.41) | SIRT3TDP1KDM5ACYP2E1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |