Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14570539 | 0.84 | TOP2A (0.53) | TOP2AMAPTKDM4EALDH1A1POLB | |
| SCHEMBL16166309 | 0.82 | POLB (0.57) | MAPTKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL11404912 | 0.82 | MAPT (0.45) | MAPTKDM4EALDH1A1MGLLPOLB | |
| SCHEMBL4823915 | 0.81 | TOP2A (0.51) | TOP2AMAPTKDM4EALDH1A1POLB | |
| SCHEMBL15383209 | 0.81 | MAPT (0.57) | TOP2AMAPTKDM4EALDH1A1POLB | |
| SCHEMBL23673315 | 0.81 | MAPT (0.51) | TOP2AMAPTKDM4EALDH1A1POLB | |
| SCHEMBL23673305 | 0.81 | TOP2A (0.51) | TOP2AMAPTKDM4EALDH1A1POLB | |
| SCHEMBL15899524 | 0.81 | MAPT (0.62) | MAPTKDM4EALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL5009825 | 0.81 | TOP2A (0.64) | TOP2AMAPTKDM4EALDH1A1PDE5A | |
| SCHEMBL7654478 | 0.80 | MCHR1 (0.41) | MAPTKDM4EALDH1A1MGLLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098888-A1 | PIPERAZINONE DERIVATIVES AND THEIR USES | LABORATOIRE L. LAFON (FR) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004000-A1 | PIPERAZINONE DERIVATIVES AND THEIR USES | LABORATOIRE L. LAFON (FR) | 2000-01-27 | — | — | WO | disclosed |