Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444878 | 0.89 | TOP2A (0.51) | TOP2ACYP1A2CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL7449001 | 0.78 | CYP1A2 (0.42) | CYP1A2CYP2D6MAPTMAPK1 | |
| SCHEMBL7450959 | 0.77 | CCNE2 (0.40) | CYP1A2MEN1KMT2AMAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL7449395 | 0.77 | CYP1A2 (0.41) | CYP1A2CYP2D6MAPTMAPK1 | |
| SCHEMBL7434912 | 0.75 | TOP2A (0.47) | TOP2ACSNK2A1POLBTLR9 | |
| SCHEMBL13312455 | 0.73 | FLT3 (0.54) | TOP2ACYP1A2CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL7441653 | 0.69 | KDM4E (0.43) | CYP3A4HSD17B10TSHRALDH1A1USP2 | |
| SCHEMBL4088578 | 0.69 | CYP1A2 (0.72) | TOP2ACYP1A2CYP3A4CYP2D6HSD17B10 | |
| SCHEMBL1284831 | 0.69 | MAPT (0.58) | CYP1A2CYP3A4CYP2D6HSD17B10TSHR | |
| SCHEMBL1085859 | 0.68 | ACP1 (0.71) | CYP1A2CYP3A4CYP2D6HSD17B10CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799221-A1 | QUINAZOLINES AS INHIBITORS OF ENDOTHELIN CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019474-A1 | QUINAZOLINES AS INHIBITORS OF ENDOTHELIN CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | claimed |
| EP-0799221-B1 | QUINAZOLINES AS INHIBITORS OF ENDOTHELIN CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-30 | — | — | EP | disclosed |
| US-5773444-A | Quinazolines as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0799221-A1 | QUINAZOLINES AS INHIBITORS OF ENDOTHELIN CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5658902-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1996019474-A1 | QUINAZOLINES AS INHIBITORS OF ENDOTHELIN CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1996-06-27 | — | — | WO | disclosed |