Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 20/20 | 0.73 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.67 |
| ▸ | MUSK | O15146 | 1/20 | 0.67 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.67 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | PAK3 | O75914 | 1/20 | 0.67 |
| ▸ | STK10 | O94804 | 1/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.67 |
| ▸ | ABL1 | P00519 | 1/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | CSF1R | P07333 | 1/20 | 0.67 |
| ▸ | YES1 | P07947 | 1/20 | 0.67 |
| ▸ | LYN | P07948 | 1/20 | 0.67 |
| ▸ | RET | P07949 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | KIT | P10721 | 1/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL74136 | 0.99 | FLT3 (0.75) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL75315 | 0.94 | FLT3 (0.76) | FLT3KDRBMPR1BMUSKEPHB6 | |
| Hydrochloric Acid SCHEMBL74908 | 0.94 | FLT3 (0.75) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL73532 | 0.89 | FLT3 (0.72) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL75277 | 0.89 | FLT3 (0.73) | FLT3KDRBMPR1BMUSKEPHB6 | |
| Hydrochloric Acid SCHEMBL73125 | 0.89 | FLT3 (0.71) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL74646 | 0.88 | FLT3 (0.75) | FLT3KDRBMPR1BMUSKEPHB6 | |
| Hydrochloric Acid SCHEMBL73677 | 0.88 | FLT3 (0.72) | FLT3KDRBMPR1BMUSKEPHB6 | |
| Hydrochloric Acid SCHEMBL73131 | 0.87 | FLT3 (0.74) | FLT3KDRBMPR1BMUSKEPHB6 | |
| SCHEMBL73192 | 0.87 | FLT3 (0.74) | FLT3KDRBMPR1BMUSKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129374-B2 | Method of using imidazolothiazole compounds for the treatment of disease | AMBIT BIOSCIENCE CORPORATION (US) | 2012-03-06 | — | — | US | claimed |
| EP-2410987-A1 | METHODS OF TREATMENT USING COMBINATION THERAPY | Ambit Biosciences Corporation (US) | 2012-02-01 | — | — | EP | disclosed |