Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444021 | 0.81 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DTLR8 | |
| SCHEMBL7441469 | 0.80 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DTLR8 | |
| SCHEMBL7445548 | 0.76 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7449668 | 0.74 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7445568 | 0.72 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DADORA1 | |
| SCHEMBL7448506 | 0.72 | PDE4D (0.49) | PDE4APDE4BPDE4CPDE4DSUCNR1 | |
| SCHEMBL7432926 | 0.70 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7441680 | 0.69 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7432915 | 0.69 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL7443517 | 0.69 | TOP1 (0.56) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |