Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21742075 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL21742014 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL21742083 | 0.85 | CHRM2 (0.44) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL21742176 | 0.82 | AHR (0.42) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL21742326 | 0.80 | BLM (0.43) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL23364963 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL29828412 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL30471943 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL12717402 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM | |
| SCHEMBL26835113 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2L3MBTL1CHRM2CYP2D6BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |