Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | HRH1 | P35367 | 3/20 | 0.58 |
| ▸ | IDO1 | P14902 | 3/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8300848 | 0.92 | IDO1 (0.56) | HTR2AHRH1IDO1CYP19A1RET | |
| SCHEMBL31536940 | 0.86 | IDO1 (0.59) | HTR2AHRH1IDO1CYP19A1RET | |
| SCHEMBL6992991 | 0.86 | IDO1 (0.59) | HTR2AHRH1IDO1CYP19A1RET | |
| Hydrochloric Acid SCHEMBL7212472 | 0.84 | IDO1 (0.62) | HTR2AHRH1IDO1CYP19A1RET | |
| SCHEMBL10530881 | 0.78 | IDO1 (0.50) | HTR2AHRH1IDO1CYP19A1GBA1 | |
| SCHEMBL7263051 | 0.77 | IDO1 (0.48) | IDO1CYP19A1CYP2D6CYP2C19GBA1 | |
| SCHEMBL714536 | 0.77 | HTR2A (0.52) | HTR2AHRH1IDO1CYP19A1RET | |
| SCHEMBL29593942 | 0.77 | HTR2A (0.52) | HTR2AHRH1IDO1CYP19A1RET | |
| SCHEMBL8291564 | 0.76 | IDO1 (0.49) | HTR2AHRH1IDO1CYP19A1GBA1 | |
| SCHEMBL9838348 | 0.75 | IDO1 (0.47) | HTR2AIDO1CYP19A1HTR2CCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2221296-B1 | FUSED INDANE COMPOUND | ASTELLAS PHARMA INC (JP) | 2012-09-05 | — | — | EP | disclosed |
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |