Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 20/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 20/20 | 0.73 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439925 | 0.96 | PDE3B (0.79) | PDE3BPDE3AP2RY12PDE2A | |
| Hydrochloric Acid SCHEMBL7433676 | 0.88 | PDE3B (0.77) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL7434936 | 0.87 | PDE3B (0.78) | PDE3BPDE3AP2RY12PDE2A | |
| Alcohol SCHEMBL7442534 | 0.85 | PDE3B (0.94) | PDE3BPDE3A | |
| Alcohol SCHEMBL7442573 | 0.81 | PDE3B (0.95) | PDE3BPDE3A | |
| Alcohol SCHEMBL7441571 | 0.81 | PDE3B (0.74) | PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL7433319 | 0.81 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL7437822 | 0.81 | PDE3B (0.76) | PDE3BPDE3AP2RY12PDE2A | |
| SCHEMBL7439976 | 0.81 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL7432571 | 0.80 | PDE3B (0.86) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196428-A | Anticoagulants | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-03-23 | — | — | US | disclosed |