Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439316 | 0.99 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPSMB5 | |
| SCHEMBL7445534 | 0.89 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPSMB5 | |
| SCHEMBL7438491 | 0.85 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DTRPV1 | |
| SCHEMBL7440477 | 0.83 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DTRPV1 | |
| SCHEMBL7446525 | 0.82 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DTRPV1 | |
| SCHEMBL7443375 | 0.81 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPSMB5 | |
| SCHEMBL7440932 | 0.81 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DTRPV1 | |
| SCHEMBL31026581 | 0.80 | CCR1 (0.53) | TRPV1TDP1L3MBTL1 | |
| SCHEMBL11686678 | 0.80 | TRPV1 (0.59) | TRPV1L3MBTL1 | |
| SCHEMBL31026591 | 0.80 | CCR1 (0.53) | TRPV1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |