Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 15/20 | 0.61 |
| ▸ | PLG | P00747 | 6/20 | 0.49 |
| ▸ | F2 | P00734 | 5/20 | 0.41 |
| ▸ | KLK1 | P06870 | 4/20 | 0.41 |
| ▸ | PLAT | P00750 | 4/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.39 |
| ▸ | CDC25B | P30305 | 2/20 | 0.39 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7336358 | 0.87 | PLAU (0.61) | PLAUPLGF2KLK1PLAT | |
| Trifluoroacetic Acid SCHEMBL7343080 | 0.77 | PLAU (0.57) | PLAUPLGF2PRSS1 | |
| Trifluoroacetic Acid SCHEMBL7336439 | 0.75 | PLAU (0.45) | PLAUF2PRSS1 | |
| Trifluoroacetic Acid SCHEMBL7336904 | 0.74 | PLAU (0.59) | PLAUPLGF2KLK1PLAT | |
| Trifluoroacetic Acid SCHEMBL7337591 | 0.74 | PLG (0.51) | PLAUPLGF2KLK1PLAT | |
| Trifluoroacetic Acid SCHEMBL7340769 | 0.74 | PLAU (0.64) | PLAUPLGF2KLK1PLAT | |
| Trifluoroacetic Acid SCHEMBL7337885 | 0.74 | PLAU (0.55) | PLAUPLGF2KLK1PLAT | |
| Trifluoroacetic Acid SCHEMBL7337301 | 0.73 | PLAU (0.64) | PLAUPLGF2KLK1PLAT | |
| Trifluoroacetic Acid SCHEMBL7456113 | 0.73 | PLAU (0.63) | PLAUPLGF2KLK1PLAT | |
| Trifluoroacetic Acid SCHEMBL7343433 | 0.73 | PLAU (0.63) | PLAUPLGF2KLK1PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000018-A2 | UROKINASE INHIBITORS | Abbott Laboratories (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005096-A2 | UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1999-02-04 | — | — | WO | disclosed |