Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 14/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | GAPDH | P04406 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146733 | 0.86 | ADORA2A (0.47) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL21313152 | 0.84 | ADORA2A (0.51) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL7396653 | 0.79 | ADORA2A (0.43) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL7146915 | 0.79 | ADORA2A (0.51) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL16229314 | 0.79 | HPGD (0.48) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL12495836 | 0.79 | ADORA2A (0.55) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL7146794 | 0.78 | ADORA2A (0.49) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL12496524 | 0.77 | HPGD (0.47) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL12496017 | 0.76 | ADORA2A (0.58) | HPGDKDM4ENPSR1ADORA2AADORA1 | |
| SCHEMBL21313215 | 0.76 | ADORA2A (0.47) | HPGDKDM4ENPSR1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261327-A2 | ADENOSINE RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062233-A2 | ADENOSINE RECEPTOR MODULATORS | F. HOFFMANN LA ROCHE AG (CH) | 2001-08-30 | — | — | WO | disclosed |