Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 20/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449598 | 0.87 | HPGD (0.84) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL7503886 | 0.86 | HPGD (0.70) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL23680648 | 0.81 | HPGD (1.00) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL22777191 | 0.81 | HPGD (1.00) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL29480994 | 0.81 | HPGD (1.00) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL5900762 | 0.81 | FGFR1 (0.68) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL23680651 | 0.77 | HPGD (1.00) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL14008299 | 0.76 | HPGD (0.71) | HPGDALDH1A1 | |
| SCHEMBL23680650 | 0.75 | HPGD (1.00) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL2653778 | 0.75 | HPGD (0.58) | HPGDALDH1A1NPC1GLARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968191-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-01-05 | — | — | EP | claimed |
| WO-1998034923-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-08-13 | — | — | WO | claimed |
| US-6071909-A | Phenylbenzimidazole derivatives as ligands for GABA receptors | MERCK SHARPE & DOHME LTD. (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0968191-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998034923-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-08-13 | — | — | WO | disclosed |