Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.58 |
| ▸ | ACE | P12821 | 3/20 | 0.58 |
| ▸ | CPA1 | P15085 | 3/20 | 0.58 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.58 |
| ▸ | ECE1 | P42892 | 15/20 | 0.57 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.52 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230086 | 0.88 | ECE1 (0.60) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7454422 | 0.84 | ECE1 (0.63) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7230545 | 0.83 | ECE1 (0.63) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7223987 | 0.82 | ECE1 (0.69) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7454534 | 0.82 | ECE1 (0.80) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7224426 | 0.81 | MME (0.68) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7229963 | 0.79 | ECE1 (0.82) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7975857 | 0.79 | ECE1 (0.57) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7221922 | 0.79 | MME (0.72) | MMEACECPA1ACE2ECE1 | |
| SCHEMBL7224058 | 0.78 | ECE1 (0.61) | MMEACECPA1ACE2ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423727-B1 | Certain thiol inhibitors of endothelin-converting enzyme | NOVARTIS AG (CH) | 2002-07-23 | — | — | US | disclosed |
| EP-1073674-A1 | THIOL INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | Novartis AG (CH) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055726-A1 | CERTAIN THIOL INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME | NOVARTIS AG (CH) | 1999-11-04 | — | — | WO | disclosed |