Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 13/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 13/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452878 | 0.88 | GRIN1 (1.00) | GRIN1GRIN2BF2PGR | |
| SCHEMBL7512485 | 0.87 | GRIN1 (0.77) | GRIN1GRIN2BF2SMN1; SMN2PGR | |
| SCHEMBL7509280 | 0.86 | GRIN1 (0.76) | GRIN1GRIN2BF2HPGD | |
| SCHEMBL7518591 | 0.86 | GRIN1 (0.75) | GRIN1GRIN2BF2PGR | |
| SCHEMBL7513211 | 0.86 | GRIN1 (0.75) | GRIN1GRIN2BF2ALDH1A1LMNA | |
| SCHEMBL7502977 | 0.86 | GRIN1 (0.75) | GRIN1GRIN2BF2PGR | |
| SCHEMBL7516788 | 0.85 | GRIN1 (0.74) | GRIN1GRIN2BF2PGR | |
| SCHEMBL7456255 | 0.85 | GRIN1 (1.00) | GRIN1GRIN2BF2 | |
| SCHEMBL7510373 | 0.84 | GRIN1 (0.73) | GRIN1GRIN2BF2PGR | |
| SCHEMBL7511558 | 0.84 | GRIN1 (0.72) | GRIN1GRIN2BF2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242076-A4 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | claimed |
| EP-1242076-A1 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-09-25 | — | — | EP | claimed |
| US-6316474-B1 | TREATMENT OF PAIN, SCHIZOPHRENIA, PARKINSON'S DISEASE, STROKE AND DEPRESSION | MERCK & CO., INC. | 2001-11-13 | — | — | US | claimed |
| WO-2001032174-A1 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | claimed |
| EP-1242076-A4 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1242076-A1 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001032174-A1 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |