Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449325 | 1.00 | TDP1 (0.61) | TDP1L3MBTL1SIGMAR1IDO1MEN1 | |
| SCHEMBL626848 | 1.00 | TDP1 (0.61) | TDP1L3MBTL1SIGMAR1IDO1MEN1 | |
| SCHEMBL8048487 | 1.00 | TDP1 (0.61) | TDP1L3MBTL1SIGMAR1IDO1MEN1 | |
| SCHEMBL7448881 | 1.00 | TDP1 (0.61) | TDP1L3MBTL1SIGMAR1IDO1MEN1 | |
| SCHEMBL198056 | 0.98 | IDO1 (0.58) | TDP1L3MBTL1SIGMAR1IDO1MEN1 | |
| SCHEMBL196951 | 0.90 | IDO1 (0.67) | TDP1L3MBTL1SIGMAR1IDO1MEN1 | |
| SCHEMBL454150 | 0.90 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1IDO1MEN1 | |
| SCHEMBL2670017 | 0.90 | KCNH2 (0.59) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL9574223 | 0.90 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1IDO1MEN1 | |
| SCHEMBL22268758 | 0.90 | KCNH2 (0.59) | TDP1L3MBTL1SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977743-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049152-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |